Nano Polymeric Biodegradable of Alginate-Arginine for Breast Anticancer Drug Delivery

In this study, etoposide (ETO), a typical chemotherapeutic agent, was selected as themodeldrug to evaluate of cysteine-modified sodium alginate (SA) nanoparticlesto load drug. Thestructure of nanoparticles was elucidated by fourier transform infrared spectroscopy (FTIR)(Fig. 1). The shape, and morphology were determined by scanning electron microscopy(SEM).In characterising the nanoparticles, physicochemical properties of particle size, polydispersityindex (PDI), zeta potential (ZP), encapsulation efficacy (EE) and drug loading (DL)were investigated. The mean size, PDI and ZP of the obtained drug loaded nanoparticleswere reported tobe 355.4nm, 0.309and -27.7 mV, respectivel [1,2]. The encapsulation efficiency,was between 80.50 and 90.77. Morever drug loading and drug release properties ofthe nanoparticles loaded with paclitaxel were also studied.The in-vitro drug release was studiedby using UV–Visible spectrophotometer at acidic environment (pH 5.0) and physiological pH(pH 7.4) and sustained release compared to the ETO alone. It was found that ETO drug is releasedmuch faster in pH 5.0 than in the pH 7.4.