Green Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by a Novel LDH Modified Clinoptilolite Nanocatalyst

Fused pyrimidine derivatives have participated in the structure of various medicinally significantcompounds especially as the privileged motifs for anticancer agent’s design purposes [1].Among fused pyrimidine derivatives, pyrido [2,3-d]pyrimidines have been the subject ofstudy in recent years for their diverse bioactivity effects [2, 3]. In the present study, somenovel pyrido [2,3-d]pyrimidine derivatives were synthesized through a green and efficientmulticomponent procedure in the presence of a novel prepared LDH modified Clinoptilolitenanocatalyst. 4(6)-Aminouracil derivative, malononitrile, benzaldeyhyde derivatives wereused as starting materials in the presence of the designed nanocatalysts in DMF as medium.This protocol has been previously reported under several reaction conditions [4]. The reactionswere carried out smoothly and the products were obtained with good to excellent yieldswithin relative short reaction times. The nanocatalyst was easily separated by centrifugationfrom the reaction mixture. The products were simply obtained by aqueous dilution of the organiclayer and washed with hot ethanol whenever necessary.