Co(NO3)2: An Efficiental Catalyst for Synthsis of Dihydropyrimido[4,5- b]quinolinetrione Derivatives Using a Multi-Component Reaction

Pyrimidine derivatives have a biological and medicinal activity such as anticancer and antihumanimmunodeficiency virus (HIV). Pyrimidine fused heterocycles have attracted great interestand biological activities such as inflammatory, antioxidant, anticancer, antitumour, antimicrobial,and antiviral actions from pyrimidine fused heterocycles have been reported.Many of alkaloids, drugs, antibiotics, agrochemicals, and natural products contain pyrimidinefused heterocycles [1]. Multicomponent reactions (MCRs) are an attractive strategy, in thefield of medicinal chemistry and used to obtain desired biologically active compounds [2]. Inthis study Co(NO3)2 has been introduced as efficient catalyst for synthesis of the novel8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trionederivatives via a four-component reaction of aldehydes, amines, dimedone, and barbituricacid with high efficiency and sutable time.