Green Synthesis of Novel 1,2,4-Triazole-3-thione Derivatives in Natural Deep Eutectic Solvent

1,2,4-Triazoles are biologically active compounds which prepared via a variety of syntheticmethods [1]. Some multicomponent and one-pot procedures were also developed for theirpreparation. Deep eutectic solvents (DESs) as environmentally friendly solvents were widelyapplied in different chemical processes [2, 3]. As part of our current studies on the developmentof new routes in organic synthesis, we report an efficient and green procedure for thesynthesis of functionalized 1,2,4-triazoles-3-thione derivatives under optimized conditions viareaction of aryl hydrazides and alkyl or aryl isothiocyanates (fig. 1). Glycerol/potassium carbonatewas used as catalyst and reaction media. 1,2,4-Triazoles-3-thione derivatives were obtainedin very good yields without the need for additional purification steps.