One-Pot Condensation Approach for the Synthesis of Tetrahydrobenzo [b] pyran Derivatives Utilizing Salicylic Acid as an Efficient and Ecofriendly Catalyst
محل انتشار: بیست و ششمین سمینار شیمی آلی ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 279
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شناسه ملی سند علمی:
ISOC26_029
تاریخ نمایه سازی: 2 شهریور 1398
چکیده مقاله:
In recent years, the synthesis of pyran derivatives, especially tetrahydrobenzo[b]pyrans, hasreceived an increasing interest because of attractive pharmacological and biological properties[1]. These compounds are also used in the industry as optical brighteners, laser dyes, pigments,cosmetics and potent biodegradable agrochemicals [1-3]. In a continuation of our endeavorstowards the development of new catalytic protocol, we wish to report an efficientone-pot, three-component strategy for the rapid synthesis of dimedone (1 mmol), malononitrile(1 mmol), aldehyde (1 mmol) in the presence of a catalytic amount (20 mol %) of salicylicacid in EtOH/H2O at 70 °C. The advantages of this protocol are higher product yields inshorter reaction times, easy work-up, and available of the catalyst (Fig .1)
نویسندگان
Tahereh Rastegar
Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, Iran
Mahboobeh Rezaie Khahkhaie
Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, Iran
Nourrolah Hazeri
Department of Chemistry, Faculty of Science, University of Sistan and Baluchistan, Zahedan, Iran