Lactose: A Novel and Green Catalyst for an Environmental Synthesis of Medicinally Important Pyrano[3,2-c]pyrazoles

Pyrano[2,3-c]pyrazoles are an important class of heterocyclic compounds that are known tobe biological agents. they play an essential role such as anti-HIV [1], antibacterial, antifungal[2], anticancer and anti-inflammatory activities [3]. In this study, A simple, high yielding andexpeditious one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazole derivativeshas been investigated using Lactose as a green catalyst (Fig. 1). The influence of reactionparameters like reaction temperature, time, the amount of catalyst, type of solvent andthe amount of catalyst were investigated with respect to yield of pyrano[2,3-c]pyrazoles. Thereported approach shows significant advantages such as operational simplicity, the use of aninexpensive and non-toxic catalyst, high yields, short reaction time, and ease of product isolationwithout chromatographic separation.