Transition Metal Catalyzed Organic Transformations

Transition metal-catalyzed reactions are some of the most attractive methodologies for synthesizingpotentially active organic compounds, since a transition-metal catalyzed reactioncan directly construct complicated molecules from readily accessible starting materials undermild conditions [1]. The transition-metal-catalyzed isocyanide insertion reaction as an importantand modern strategy has received broad attention recently compared to traditionalmethods for the organic molecules synthesis which gives an atom economical, simple and directsynthetic strategy to complex and structurally diverse molecules using simple substrate[2]. Similarly, homocoupling reactions are the operators of the symmetrical compound productionswithin the synthetic chemist’s repertoire. Typically, the metal-catalyzed synthesis ofthese reactions involves the reaction of (hetero) aryl halides or pseudohalides, oxidativehomocouplingof organometallic reagents and direct C–H bond functionalization (dehydrogenativehomocoupling) [3]. In this lecture, new transition-metal-catalyzed isocyanide insertionreactions for the synthesis of new potentially active compounds will be discussed. In secondpart, some new transition-metal-catalyzed, CN-directed unsymmetrical synthesis of bithiophenesvia an unprecedented homocoupling reaction will be described.