Eugenol recovers some endocrine and histological changes in a rat model of polycystic ovary syndrome

Background: Polycystic ovary syndrome or PCOS is one of the most common cases of infertility among women of reproductive age. It is an endocrine disorder with inflammatory aspects leading to lack of ovulation. Eugenol is an active phenolic constituent of clove essential oil with the anti-inflammatory properties.Objective: The aim of this study was to evaluate the therapeutic effects of eugenol in rats suffering from PCOSMaterials and Methods: 32 adult Wistar rats were divided into four groups of control, PCOS, PCOS + intra peritoneal injection of eugenol (12 and 24 mg/kg) for 30 days. The induction of syndrome was done by intra peritoneal injection of 4 mg of Estradiol valerate for 28 days. Control group received no injection. At the end of the trial, the serum and ovary of all groups were collected in order to investigate the histological and serological changes. One-Way ANOVA (one way analysis of variance) with Tukey test was used for analyzing the data and comparison of the different group means.Results: Administration of eugenol decreased the serum level of estradiol and LH hormone and increased the serum level of FSH in treated rats when compared with PCOS rats (p<0.05). A significant increase was observed in the number of corpus luteum in the eugenol-treated groups compared with PCOS group (p<0.05).Conclusion: Our results suggest that eugenol has improvement effects on an ovarian function and ovulation in the PCOS rat model. Therefore, it could be use as a protective agent and as an adjunct treatment in PCOS patients.

کلیدواژه ها:

Polycystic Ovary Syndrome ، Eugenol ، Rat