Molecular evaluation of endometrial receptivity in women with congenital malformations of genital tract

Background: Uterine congenital malformations (UCM) occur in 3-4% of women overall, in 4% of infertile women and in 15% of those who have experienced recurrent miscarriage. Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is ∼4.3%, in infertile patients ∼3.5% and in patients with recurrent pregnancy losses ∼13%. Septate uterus is the commonest uterine anomaly with a mean incidence of ∼35% followed by bicornuate uterus (∼25%) and arcuate uterus (∼20%). To present the potential clinical impact which uterine congenital malformations (UCM) may exert on human embryonic implantation and discuss in receptive endometrium genes.Objective: In this study, differences in gene expression between UCM and normal endometrium were evaluated using a PCR Array approach.Materials and Methods: The mRNA of endometrium was analyzed in 3 groups (septet uterus, unicorn uterus, normal uterus, n=15). The differentially expressed genes of receptivity endometrium pathway were analyzed.Results: The mRNA levels of expression in EGF, CSF, HOXA10, HOXA11, LIF, LIFR, MUC1 were all significantly higher in the unicorn group compared to control (p<0.05) but EGF, CSF, HOXA10, HOXA11, LIFR, MUC1 were all significantly lower in the septate group compared to control (p<0.05). However, LIF was expressed higher in septate group compared to control (p<0.05).Conclusion: This investigation showed that the patients with UCM have different pattern of endometrial receptivity. Further research should be done to clarify the endometrial receptivity in different type of uterine anomaly.

کلیدواژه ها:

Endometrium receptivity ، Congenital malformations ، PCR array ، Uterine ، Genital tract