The risk of hypertension in polycystic ovary syndrome: long-term population-based cohort study

Background: Polycystic ovary syndrome (PCOS) is one the most common endocrinopathies associated with metabolic complications, Whether PCOS is associated increased risk of hypertension with independent of potential confounders’ remains controversial.Objective: The aim of this study was to evaluate the hazard of hypertension in women with polycystic ovary syndrome (PCOS) comparing with control group of healthy women.Materials and Methods: This study was prospective cohort study with the median and interquartile range of 12.9 (10.8-13.9) yr. The participants of this study was selected from among women participating in Tehran Lipid and Glucose Study. A total of 1,702 reproductive-age women including 178 women with PCOS and 1,524 controls were recruited. The main outcome measure was cumulative incidence of hypertension using the Kaplan-Meier method and compared using the log-rank statistic; univariate and multiple extended Cox proportional hazards regression with age as the time scale was used to estimate the adjusted hazard ratio (HR) of developing hypertension.Results: The incidence rates of hypertension were 13.9, per 1,000 person-years for women with PCOS; and 13.8 per 1,000 person-years for the healthy control women. Women with PCOS aged lower than 40 years had an adjusted higher risk of developing hypertension (HR 2.08; 95% confidence interval, 1.0-3.9), but the risk disappeared after age 40.Conclusion: In this long-term population-based cohort study, the risk of developing hypertension in young women with PCOS was higher than in controls, but these risks were diluted in the late reproductive period.

کلیدواژه ها:

Polycystic ovary syndrome ، Population-based cohort study ، Hypertension