Study the association of two key polymorphisms in H2BFWT gene with idiopathic male infertility
محل انتشار: هشتمین کنگره بین المللی و جشنواره دانشجویی طب تولید مثل و سومین کنگره بین المللی ژنتیک تولید مثل
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 325
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شناسه ملی سند علمی:
RMED08_179
تاریخ نمایه سازی: 21 مرداد 1398
چکیده مقاله:
Background: H2BFWT is one of the testis-specific histones that plays an important role in spermatogenesis process and single nucleotide polymorphisms (SNPs) in this gene may lead to male infertility.Objective: In this study, the relation of -9 C> T and 368 A> G transitions in H2BFWT gene with male infertility has been investigated in Kashan population.Materials and Methods: In a case-control study, the blood sample was collected from 232 subjects including 109 patients with idiopathic male infertility and 123 fertile men. The genotypes of -9 C> T and 368 A> G polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Our data showed that alleles -9T (95%CI: 1.75, OR: 1.04-2.95, p=0.035) and 368G (95%CI: 1.71, OR: 1.02-2.89, p=0.042) are associated with male infertility. Also, subgroup analysis revealed that -9 C> T polymorphism was associated with azoospermia while 368 A> G was associated with oligozoospermia.Conclusion: Based on our findings, 368 A> G and -9 C> T polymorphisms can be considered as genetic risk factors for infertility in the male population of Kashan.
کلیدواژه ها:
نویسندگان
L Parvaresh
Department of Medicine, Kashan University of Medical Sciences, Kashan, Iran
M Karimian
Department of Medicine, Kashan University of Medical Sciences, Kashan, Iran
T Mazoochi
Department of Medicine, Kashan University of Medical Sciences, Kashan, Iran