Cleavage-stage embryo micromanipulation in the ART program

Embryo micromanipulation is one of the routine tasks which performs at any ART clinic worldwide. Embryo micromanipulation was developed specially after introduction of intracytoplasmic sperm injection. Maybe more micromanipulations are performed at cleavage-stage embryos. A wide range of techniques belongs to embryo micromanipulation including assisted hatching, removing detrimental components from healthy embryos, blastomere biopsy, and embryo splitting. The main question may raise is when these techniques should be used and which side effects may they have. Besides, the safety of micromanipulation techniques should be taken into account.