Dietary Patterns and the risk of Colorectal Cancer and adenoma

Background: Dietary patterns have been shown to be associated with risk of colorectal cancer risk, but there are a few data on this context and its relationship with risk of colorectal adenomas as the precursors of the colorectal cancer. The aim of this study is to examine the relationship between dietary patterns and the risk of Colorectal Cancer and adenomas. Methods: This hospital-based case-control study was conducted in three major general hospitals in Tehran province, Iran. Data was collected from 129 colorectal cancer and 130 colorectal adenoma patients that confirmed by pathology and colonoscopy findings and 240 controls with non-neoplastic conditions and not afflicted with diet related chronic diseases. Dietary data were evaluated by 147-items semi-quantitative food frequency questionnaire. Multivariate logistic regression was used to estimate the relationship between dietary patterns and risk of colorectal cancer and colorectal adenoma. Results: Three dietary patterns (healthy, western and traditional) were derived. After adjusting for confounding factor, the healthy dietary pattern was associated with decreased risk of CRC (OR=0.22, 95% CI=0.13-0.36) and CRA (OR=0.46, 95% CI=0.28-0.75), Higher adherence to the Western dietary pattern was positively associated with risk of CRC (OR=3.18, 95% CI=1.95-5.18) and CRA (OR=2.12, 95% CI=1.31-3.46). There was no significant association between Traditional pattern and the CRC (OR=97, 95% CI=0.61-1.56) and CRA (OR=0.86, 95% CI=0.53-1.38) risk. Conclusion: Our study suggested that the Healthy dietary pattern reduces the risk of CRC and CRA, while the Western dietary pattern increases the risk of both CRC and CRA.

کلیدواژه ها:

Dietary pattern ، Colorectal cancer ، Colorectal adenoma ، Healthy dietary pattern ، Western dietary pattern