Recent craniomaxillofacial bone tissue engineering

There are several possibilities in order to bone regeneration including, the autologous bone which considered as a gold standard , bone allograft or xenografts which prepared by the demineralization process or radiation to reduce the risk of disease transmission, bone biocompatible materials such as metals, ceramics, polymers, and composites. In this study, main strategies for Bone Tissue Engineering (BTE) and bone TE specifications which currently used in the clinic have been explained. Depending on the location of new tissue formation, strategies are divided in: in vivo and ex vivo tissue engineering (Assembly and static culture of bone substitutes, seeding of cells dynamically and alternative culture bone, Engineering Step by step of synthetic bone substitutes). Generally, components of a bone substitute are Osteogenic cells, Biomaterial scaffolds, and Osteoinductive signals: Growth factors. Examples of TE bone substitutes and TE bone products, which were used in clinical case reports and clinical studies, are: TE Bone Products Containing Osteoconductive Scaffolds with Osteoinductive Factors, Custom-Made TE Bone Substitutes Containing Viable Cells for the Treatment of Individual Patients, Commercial TE Bone Products Containing Viable Cells such as BioSeed-Oral Bone, Osteocell, Tissue Repair Cells, NeoFuseDue to differences between the study design, absence of control groups, and differences in clinical indications, the comparison between the studies is difficult and currently does not provide firm conclusions regarding the optimal TE protocols. It is believed that with further technological advances that TE bone products will be further improved to wider clinical application.

کلیدواژه ها:

Bone tissue engineering ، BTE ، TE bone products ، Regeneration ، Clinical application