Naringin-loaded poly (ɛ-caprolactone)/gelatin electrospun film as a potential wound dressing: in vitro and in vivo evaluation

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated into poly (ɛ-caprolactone)/gelatin composite films in order to develop a potential wound dressing. The composite films were prepared by electrospinning of poly (ɛ-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.5, 3 and 6% (w/w) of naringin. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with naringin-loaded dressings achieved a wound closure of higher than 94% and the dressing containing 6% (w/w) naringin had almost 100% wound closure. The sterile gauze, as the negative control, showed nearly 86% of wound closure after this period of time. Our results provided evidence supporting the possible applicability of naringin-loaded wound dressing for successful wound treatment

کلیدواژه ها:

Wound dressing ، Naringin ، Poly (ɛ-caprolactone) ، Gelatin ، Electrospinning