The potentials of fetal stem cells in wound healing

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 268

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شناسه ملی سند علمی:

ITERMED01_307

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

According to research conducted by various researchers, Wharton’s Jelly mesenchymal stem cells (WJMSCs) have several advantages compared to others sources, in regenerative medicine: WJMSCs are more primary cells; WJMSCs can be easily isolated and without invasive procedures; WJMSCs have no ethical problems; WJMSCs are more cost effective than other sources of MSCs. Also, WJMSCs were demonstrated to express stem cell mesenchymal markers. As a challenge that WJMSC transplantation has not yet been approved by the Food and Drug Administration and that clinical trials of MSC transplantation, showing no adverse events, have not yet reached the 10-year mark, WJMSCs have not been extensively used for clinical therapies. In addition, a number of challenges and side effects in WJMSC-based therapy remain to be addressed. First, the umbilical cord is an allogeneic tissue for the recipient. The second problem is an ethical one. Although the umbilical cord is a disused organ, both the donor and the recipient have the right of informed consent. Third, a complete detection system, to test any potential disease risk in donors, has yet to be established. Fourth, the isolation and further expansion of primitive MSCs probably have several uncertain factors, such as the use of animal serum and the most common culture method in vitro, which should be avoided in clinical-grade therapy to prevent cell contact with xenogeneic proteins. Fifth, potential long term risks associated with MSC therapy that may not have been observable within a short period, after administrations have recently been confirmed in preclinical studies. Stem cell therapy is one of the most promising areas of regenerative medicine, and a number of such therapies are now under development by academic and industrial groups. As the technology of cell therapies has advanced, regulatory systems, to monitor their use, must be established. The general strategy for many adult stem cells and all pluripotent stem cell therapies is the scale up of undifferentiated stem cell production. After differentiation into a specific cell type and delivery to patients, the cells may reside indefinitely.

کلیدواژه ها:

Fetal mesenchymal stem cells ، Cell therapy ، Wound healing

نویسندگان

Sona Zare

Department of Biology, Faculty of Basic Science, Islamic Azad University, Hamedan Branch, Hamedan, Iran

Rahim Ahmadi

Department of Biology, Faculty of Basic Science, Islamic Azad University, Hamedan Branch, Hamedan, Iran

Abdolreza Mohamadnia

Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), ShahidBeheshti University ofMedical Sciences, Tehran, Iran

Mohammad Ali Nilforoushzadeh

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.