Preparation of polymeric nanocarrier through electrospray method
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 317
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شناسه ملی سند علمی:
ITERMED01_286
تاریخ نمایه سازی: 7 مرداد 1398
چکیده مقاله:
IntroductionElectrohydrodynamic atomization or electrospray (ES) has substantial benefits over other preparation methods of polymeric nanoparticle including single step preparation process, no need for surfactant or template. Besides, biological molecules in this method have lower exposure with toxic solvents and monodisperse nanoparticles are produced. Poly lactic-co-glycolic acid (PLGA) based nanoparticles have been introduced as desirable candidate for intravenous drug delivery of hydrophobic agents. Noscapine is a natural compound, which in spite of having inhibitory effect on cancerous cells, demonstrated little or no toxic effect on normal cells. However, pharmacological limitations like short plasma half-life, fast elimination from body and high effective dose hinder its clinical use. ObjectivesDue to the need for a proper carrier to encapsulate noscapine, in this study we tried to load noscapine in polymeric nanoparticles by electrospray method with proper size. MethodsNoscapine loaded methoxy polyethylene glycol PLGA (mPEG-PLGA) were prepared by electrospray set up. ResultsmPEG-PLGA nanoparticles were prepared through electrospray method with size of 228 nm. Prepared nanoparticles showed that electrospray can be a suitable method for polymeric nanoparticles preparation, although its production yield needs further development. ConclusionNoscapine loaded mPEG-PLGA nanoparticles can be successfully prepared through electrospray method and can be a desirable carrier for delivering noscapine to target site like tumors.
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نویسندگان
Seyedeh Sara Esnaashari
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Amir Amani
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran