Methods and approaches in tissue engineering for long-term electrodes

The medical electrodes have lots of usages not only in some disorders like as Seizure for recognising, treatments and prevention. But also for heart pacemakers and brain pacemakers, Cochlear implant, Peripheral Nerve Stimulation Devices. Neural electrodes have been widely used for brain research. The use of these electrodes in the brain is limited due to their inability to record neural signals for a long time. But the main problem in these electrodes is the invasive Feature of them, so these electrodes make a wound in the place where they put, and the immune system comes to the wounded site an some of the immune cells like as Microglia and macrophages produce fibrosis. In this case, the metal and bioinert electrodes couldn t work properly because of the Insulation property in the fibrous tissue that produces with immune cells and connective tissue that stimulate with trauma. So tissue engineering has lots of solutions to eliminate these obstacles, for example, using biocompatible and biodegradable materials must be a good idea for this kind of devices. By the way, until today the scientists used some synthetic and natural materials as a conductor electrode (like as chitosan) And it seems using some biological materials like as some decellularised tissue must be helpful in long-term electrodes

کلیدواژه ها:

Nerve system ، Medical electrodes ، Tissue engineering