Nanofibers of mussel-inspired polymer with the aid of PVA as a water-soluble carrier for electrospinning procedure

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 313

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شناسه ملی سند علمی:

ITERMED01_179

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

IntroductionMussels are promiscuous fouling organisms and have been shown to attach to virtually all types of inorganic and organic surfaces. In 2007, Lee, et al. developed a strategy for surface modification of multiple classes of materials, inspired by the adhesive proteins (which are rich in 3,4-dihydroxy-L-phenylalanine (DOPA) and lysine amino acids) secreted by mussels for attachment to the wet surfaces.ObjectivesIn this study, nanofibers of poly (DOPA) were prepared with the aid of PVA as a carrier for electrospinning procedure, in order to use the unique features of poly (DOPA) united with the bio-mimetic characteristics of electrospun fibers. For this purpose, it is critical for nanofibers of poly (DOPA) to remain on their bioactive form with the cathecol groups available for the adherence of cells.MethodsThe powder of both polymers was mixed together and simultaneously exposed to the solvent (Tris buffer, pH=8.5). The resulted solutions with different weight ratio of poly (DOPA) were electrospun (in DOE designed conditions). Nanofibers were crosslinked and their properties were evaluated. At the end, the maintenance of poly (DOPA) bio-adhesiveness was studied for human fibroblast cell as a model.ResultsThe cell-scaffold interaction studies showed that the bio-adhesiveness of PVA/poly (DOPA) nanofibers have preserved upon electrospinning.ConclusionThe fibrous structure of this mats united with the unique advantages of the pDA associated bio-functionalization makes this system interesting for different applications

نویسندگان

Reyhane Kalanaki

Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

Atefeh Solouk

Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

Hossein Baharvand

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran