Effects of hydrophilic polymer on structures and properties of poly-є-caprolactone-based electrospun nanofibers

Electrospinning is an effective and commonly used method for gaining acceptance nanofibrous scaffolds that have been recently used in the field of tissue engineering because of their nano-size. The scaffolds play an important role in tissue engineering, via providing a proper matrix for cell attachment, proliferation and differentiation.Nanofibers can be produced from variety of polymers and biopolymers. Polycaprolactone (PCL), a hydrophobic semicrystalline polymer with a high molecular weight, has been anxiously investigated for tissue engineeringapplications, due to properties such as low cost, non-toxicity, biodegradabilityand biocompatibility.The basic mode of degradation for caprolactone polymers is hydrolysis. Hydrolysis is affected by the size, crystallinity of the polymer, hydrophilicity, the pH and the temperature of the environment.One of the limitations of scaffolds made-up with PCL is their trivial cell scaffold interactions due to the inherent hydrophobic nature. This may lead to poor cell adhesion, migration, proliferation, and differentiation during cell culture. Thus, strategies to improve the hydrophilicity of PCL based scaffolds are necessary. Therefore, an easy approach to improve hydrophilicity is by blending or copolymerizing with hydrophilic polymers. In this study, we used Poly oxazoline as semi peptide, hydrophilic, non-toxic and biodegradable polymer, by blending with PCL, in different ratio, to improve cell attachment of mats. Also, it was used for improving structure and property of scaffold.

کلیدواژه ها:

Tissue engineering ، Electrospinning ، Polycaprolactone ، Cell attachment