The effect of nano graphene oxide on acute liver injury induced by ccl4 in rats

IntroductionLiver is the central organ for metabolism and detoxification and it is susceptible to various diseases. Cirrhosis and liver fibrosis have been considered as common problems of this organ. The use of Nano biotechnology in biology has given new therapies in medicine. Researches in grapheme and graphene based nanostructures such as graphene oxide has shown unique properties such as surface adsorption. The aim of the present research was the study of effects of nano graphene oxide on acute liver injury induced by ccl4.Methods30 mice were divided into control, sham and model groups. Acute hepatic injury was induced by intraperitoneal of ccl4.In experimental groups, a dose of 300 μl/kg body weight of magnetic graphene oxide was selected. Blood and liver tissue samples were collected after 4 days then serum activity of Alanine amino transferase (ALT), Aspartate amino transferase (AST) and necrosis as well as inflammation in the liver were studied.ResultsTreatment with nano grapheme oxide significantly decreased the activity of ALT and AST in the serum as well as the necrosis and inflammation in liver tissue. In addition the survival rate was increased in the animal receiving carbon tetrachloride.ConclusionConsidering the properties of absorption of the growth factors in the blood by magnetic graphene oxide, it seems that the intraperitoneal injection of particles causes particles to pass through the blood by absorbing growth factors and bringing them to the damaged tissue by increasing their repair speed.

کلیدواژه ها:

Nano particle ، Graphene oxide ، Liver ، Carbon tetrachloride