The role of hydrogels on tolerogenicity of encapsulated dendritic cells

IntroductionNowadays, Cell therapy has attracted many fans in the treatment of diseases like immunodeficiency, arthritis, diabetes, vision impairments as well as brain or spinal cord injuries and so on. One of the therapeutic strategies in cell transplantation is the employment of biodegradable hydrogels as a carrier, in cell delivery.ObjectivesThere is a debate in the interaction between the hydrogel and the encapsulated cells, whether the hydrogel affects the cell phenotype, function, and even survival.MethodTechnically, the porosity, stiffness, and biodegradation time influence cell behavior as well as varying types of polymers and byproducts. Encapsulated dendritic cells, modulated by 1, 25(OH) 2D3-Vitamin D3, exhibit an immature DCs phenotype in vivo model of autoimmune diseases. To memorize the tolerance property, understanding the relevance between dendritic cells and surrounding hydrogels is considerable.ResultsThe researchers were demonstrated that the modification of material properties of hydrogels used for encapsulating to lDCs confers a special immunoregulatory role in this issue.ConclusionThe fate of the encapsulated dendritic cell plays a key role in determining the effectiveness of cell-based therapy, along with the role of dose and administration route. Although the role of the microenvironment surrounding the cell has proven in the cell fate, more studies are needed in vitro and in vivo.KeywordsCell therapy, Tolerogenicity, Dendritic cell, Hydrogel

کلیدواژه ها:

Cell therapy ، Tolerogenicity ، Dendritic cell ، Hydrogel