Dendrimer modified magnetic nanoparticles for localized hyperthermia and MRI diagnosis

Over the past decades, increasing interests have been devoted to the synthesis of functionalized magnetic nanoparticles (MNPs) due to their biocompatibility, biological degradability, targeting ability and remarkable magnetic properties. Nanoparticles have high surface energy, so tend to agglomerate resulting in a loss of magnetism and dispersibility. To overcome this obstacle, it is necessary to protect nanoparticles by polymers or other agents such as dendrimers, taking into account their biocompatibility, to chemically stabilize the magnetic nanoparticles against aggregation.Considering the valuable clinical application of functionalized iron oxide nanoparticles, it is necessary to further develop the nanoscale architecture of this compound. The aim of this work was synthesizing water dispersible, dendrimer functionalized magnetic nanoparticles for cancer treatment using localized hyperthermia therapy as well as MRI contrast enhancement agent. Dendrimers with highly hydrophilic branched chains prevent the nanoparticles aggregation and make them long-term stable colloid. In this study, a precipitation method had been used for the synthesis of iron oxide nanoparticles. At first, the MNPs had been modified with (3-aminopropyl) triethoxysilane, and then PAMAM functionalized MNPs had been synthesized cycling. These MNPs had been characterized by SEM, TEM, XRD, and VSM. The toxicity of these MNPs had been evaluated by MTT. Thereafter their inductive heat property by an ac magnetic field generator and the MRI properties were investigated. We believe that these dendrimer functionalized MNPs have the potential of integrating therapeutic and diagnostic functions in a single carrier

کلیدواژه ها:

Magnetic nanoparticles ، Dendrimer ، Hyperthermia ، Magnetic resonance imaging