Tumor infiltrating cytotoxic CD8 T-Cells predict clinical outcome of neuroblastoma in children

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 326

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شناسه ملی سند علمی:

ACPLMED20_051

تاریخ نمایه سازی: 29 تیر 1398

چکیده مقاله:

Neuroblastoma is often infiltrated by inflammatory cells. One possible role of these inflammatory cells is that they represent a cell-mediated immune response against cancer. CD8+ lymphocytes are a known crucial component of cell mediated immunity. This study was to explore the prognostic value of tumor-infiltrating CD8+ cytotoxic lymphocytes in Neuroblastoma. Tumor-infiltrating CD8+ lymphocytes were assessed by immune-histochemical staining of tumor tissue from 36 neuroblastoma from April 2008 to May 2015. The number of CD8+ T-cells was counted in tumor nest (intra-tumoral) and in the fibro vascular stroma of tumor (peritumoral) and their relationship with clinicopathologic outcome was determined. The total number of CD8+ cells was inversely correlated with tumor histology grade (P<0.001), vascular invasion (P<0.001), capsular invasion (P<0.002), calcification (P<0.005), necrosis of tumor (P<0.001), regional lymph nodes invasion (P<0.003), distant metastasis (P<0.003), stage (P<0.003) and was positive correlated with N-myc oncogene presentation (P<0.002) in neuroblastoma. However, there were no correlation between patient’s age, sex and size of tumor with infiltration of CD8+ cells (P<0.097, P<0.142 and P<0.722, respectively). In this analysis, total CD8 T-cell count was a dependent prognostic factor in children. Total number and stromal CD8 lymphocytes were associated with better patient survival (P<0.003 and P<0.05, respectively) in children. CD8 T lymphocytes have antitumor activity and influence the behavior of neuroblastoma and might be potentially being exploited in the treatment of neuroblastoma.

نویسندگان

Mahtab Rahbar

Department of pathology,iran university of medical sciences,Tehran,Iran

Mitra Mehrazma

Department of pathology,iran university of medical sciences,Tehran,Iran

Mersedeh Karimian

Department of pathology,iran university of medical sciences,Tehran,Iran

Mersedeh Karimian

Department of pathology,iran university of medical sciences,Tehran,Iran