Invasive micropapillary carcinoma in a young male patient

INTRODUCTION: Micropapillary carcinoma is a rare carcinoma accounting for approximately 0.9-2% of invasive breast cancers. The vast majority of micropapillary carcinomas present as a palpable mass. Micropapillary carcinomas are characterized by the presence of hollow or morula-like aggregates of cuboidal-to-columnar neoplastic cells devoid of fibrovascular cores, surrounded by empty stromal spaces, which at first glance confer an appearance of lymphovascular invasion, but not be lined by endothelial cells. Characteristically the neoplastic cells of micropapillary carcinoma display a reverse polarity whereby the apical pole of neoplastic cells faces the empty stromal spaces. Micropapillary carcinomas significantly more frequently present with lymphovascular invasion and lymph node metastasis. The vast majority of micropapillary carcinomas are esterogen and progesterone receptor-positive with conflicting results for HER2. CASE PRESENTATION: We present here a case of micropapillary carcinoma in a 34 year-old man that was presented with a right breast mass with BIRADS of V on sonographic study. Core needle biopsy of the mass was diagnosed as infiltrating ductal carcinoma . The patient received neoadjuvant chemotherapy and then he underwent right breast mastectomy and axillary dissection. Microscopic examination of the retroareolar mass demonstrated a tumor with involvement of skin and dermal lymphovascular invasion. The majority of the mass was constituted of micropapillary carcinoma (80%) with 20% of invasive ductal carcinoma. Lymphovascular invasion and lymph node involvement were also noted. The tumor was esterogen and progesterone receptor positive (35-40% of tumoral cells) with negative staining for HER 2 receptor.CONCLUSION: Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast carcinoma in male patient. Recognition of this relatively rare entity is important in predicting metastasis to lymph nodes and distant sites regardless of tumor size. Because the occurrence of IMPC in a male breast is rare, we report our case with a review of literature

کلیدواژه ها:

Invasive micropapillary carcinoma ، Breast ، Invasive ductal carcinoma