Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 429

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شناسه ملی سند علمی:

JR_IJP-13-1_006

تاریخ نمایه سازی: 23 تیر 1398

چکیده مقاله:

Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in different grades of brain glioma was evaluated by the immunohistochemistry method to determine the probable usefulness of anti-PSMA antibody as complementary target therapy in different grades of glioma. Results: Overall, 72 cases of low (grade I and II) and high (grade III and IV) grade gliomas were evaluated for expression of PSMA. Positive PSMA staining was observed in 12 (33.3%) of high grade and 3 (8.3%) of low grade gliomas. Although, high grade tumors more commonly had positive result for PSMA (P value=0.009), the intensity of staining was significantly stronger in low-grade tumors (P value=0.009). Conclusion: Expression of PSMA in different grades of glioma might provide a basis for further investigations focusing on selective target therapy in combination with the current standard care in all glioma grades, to improve treatment efficacy.

نویسندگان

Hiva Saffar

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Maryam Noohi

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Seyed Mohammad Tavangar

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Hana Saffar

Dept. of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Iran

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