Influence of taxol and CNTs on the stability analysis of protein microtubules

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 454

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_JCAM-50-1_015

تاریخ نمایه سازی: 18 تیر 1398

چکیده مقاله:

Microtubules are used as targets for anticancer drugs due to their crucial role in the process of mitosis. Recent studies show that carbon nanotubes (CNTs) can be classified as microtubule-stabilizing agents as they interact with protein microtubules (MTs), leading to interference in the mitosis process. CNTs hold a substantial promising application in cancer therapy in conjunction with other cancer treatments such as radiotherapy and chemotherapy. In the current study, a size-dependent model is developed for the stability analysis of CNT-stabilized microtubules under radial and axial loads. A nonlocal shell theory with strain gradient effects is employed to take size influences into account. Moreover, Van der Waals interactions between CNTs and MTs are simulated. An excellent agreement is observed between the present model and reported data from experiments on protein MTs. In addition, the effects of taxol, as another stabilizing agent, on the stability of microtubules are studied. It is found that both nonlocal and strain gradient effects are essential to accurately obtain the stability capacity of MTs. Furthermore, CNTs have an increasing effect on the critical loads of microtubules while the critical loads reduce in the presence of taxol.

نویسندگان

Elaheh Rohani Rad

Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, Australia

Mohammad Reza Farajpour

Borjavaran Center of Applied Science and Technology, University of Applied Science and Technology, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Z. Liu, S. Tabakman, K. Welsher, H. Dai, Carbon nanotubes ...
  • Z. Liu, W. Cai, L. He, N. Nakayama, K. Chen, ...
  • P.-C. Lee, Y.-C. Chiou, J.-M. Wong, C.-L. Peng, M.-J. Shieh, ...
  • S. Peretz, O. Regev, Carbon nanotubes as nanocarriers in medicine, ...
  • N. M. Bardhan, D. Ghosh, A. M. Belcher, Carbon nanotubes ...
  • A. Sharma, S. Hong, R. Singh, J. Jang, Single-walled carbon ...
  • L. García-Hevia, F. Fernández, C. Grávalos, A. García, J. C. ...
  • L. Rodriguez-Fernandez, R. Valiente, J. Gonzalez, J. C. Villegas, M. ...
  • F. Gittes, B. Mickey, J. Nettleton, J. Howard, Flexural rigidity ...
  • J. M. Berg, J. Tymoczko, L. Stryer, Glycolysis is an ...
  • J. A. Kaltschmidt, A. H. Brand, Asymmetric cell division: microtubule ...
  • H. Lodish, A. Berk, S. Zipursky, P. Matsudaira, D. Baltimore, ...
  • Dielectrophoretic effect of nonuniform electric fields on the protoplast cell [مقاله ژورنالی]
  • S. Suresh, Biomechanics and biophysics of cancer cells, Acta Materialia, ...
  • F. Pampaloni, G. Lattanzi, A. Jonáš, T. Surrey, E. Frey, ...
  • M. Kurachi, M. Hoshi, H. Tashiro, Buckling of a single ...
  • A. I. Aria, H. Biglari, Computational vibration and buckling analysis ...
  • Q. Wang, V. Varadan, Application of nonlocal elastic shell theory ...
  • M. Ece, M. Aydogdu, Nonlocal elasticity effect on vibration of ...
  • M. Danesh, A. Farajpour, M. Mohammadi, Axial vibration analysis of ...
  • M. Aydogdu, I. Elishakoff, On the vibration of nanorods restrained ...
  • M. Z. Nejad, A. Hadi, A. Rastgoo, Buckling analysis of ...
  • M. Z. Nejad, A. Hadi, Non-local analysis of free vibration ...
  • A. Hadi, M. Z. Nejad, M. Hosseini, Vibrations of three-dimensionally ...
  • M. Z. Nejad, A. Hadi, A. Farajpour, Consistent couple-stress theory ...
  • M. R. Farajpour, A. Shahidi, A. Farajpour, Resonant frequency tuning ...
  • A. Farajpour, M. Mohammadi, A. Shahidi, M. Mahzoon, Axisymmetric buckling ...
  • M. Farajpour, A. Shahidi, A. Hadi, A. Farajpour, Influence of ...
  • M. Farajpour, A. Shahidi, A. Farajpour, A nonlocal continuum model ...
  • M. R. Farajpour, A. R. Shahidi, A. Farajpour, Frequency behavior ...
  • M. R. Farajpour, A. R. Shahidi, A. Farajpour, Frequency behavior ...
  • C. Wang, C. Ru, A. Mioduchowski, Orthotropic elastic shell model ...
  • H. Jiang, L. Jiang, J. D. Posner, B. D. Vogt, ...
  • T. Li, A mechanics model of microtubule buckling in living ...
  • B. Akgöz, Ö. Civalek, Application of strain gradient elasticity theory ...
  • M. Taj, J. Zhang, Analysis of wave propagation in orthotropic ...
  • A. Farajpour, A. Rastgoo, M. Mohammadi, Surface effects on the ...
  • A. G. Arani, M. Abdollahian, M. Jalaei, Vibration of bioliquid-filled ...
  • Ö. Civalek, C. Demir, A simple mathematical model of microtubules ...
  • M. A. Jordan, L. Wilson, Microtubules as a target for ...
  • C. Lim, G. Zhang, J. Reddy, A higher-order nonlocal elasticity ...
  • M. R. Farajpour, A. Rastgoo, A. Farajpour, M. Mohammadi, Vibration ...
  • L. Li, Y. Hu, L. Ling, Wave propagation in viscoelastic ...
  • A. Farajpour, A. Rastgoo, M. Mohammadi, Vibration, buckling and smart ...
  • M. Mohammadi, A. Farajpour, M. Goodarzi, R. Heydarshenas, Levy type ...
  • S. R. Asemi, A. Farajpour, Vibration characteristics of double-piezoelectric-nanoplate-systems, IET ...
  • S. R. Asemi, A. Farajpour, M. Borghei, A. H. Hassani, ...
  • A review of size-dependent elasticity for nanostructures [مقاله ژورنالی]
  • Forced vibration of piezoelectric nanowires based on nonlocal elasticity theory [مقاله ژورنالی]
  • A. Farajpour, A. Rastgoo, M. Farajpour, Nonlinear buckling analysis of ...
  • M. Goodarzi, M. Mohammadi, A. Farajpour, M. Khooran, Investigation of ...
  • S. R. Asemi, M. Mohammadi, A. Farajpour, A study on ...
  • M. Mohammadi, A. Farajpour, M. Goodarzi, H. Mohammadi, Temperature effect ...
  • A. Farajpour, A. Rastgoo, Influence of carbon nanotubes on the ...
  • M. Farajpour, A. Shahidi, F. Tabataba’i-Nasab, A. Farajpour, Vibration of ...
  • A. C. Eringen, 2002, Nonlocal continuum field theories, Springer Science ...
  • C. Li, C. Ru, A. Mioduchowski, Length-dependence of flexural rigidity ...
  • W. D. Cornell, P. Cieplak, C. I. Bayly, I. R. ...
  • نمایش کامل مراجع