Protective effect of crocin against d-galactose-induced aging in mice

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 353

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شناسه ملی سند علمی:

JR_AJP-8-1_002

تاریخ نمایه سازی: 18 تیر 1398

چکیده مقاله:

Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice. Materials and Methods: The model of aging was induced using administration of d-galactose (500 mg/kg, s. c.) for 42 days. Animals were treated with crocin (10, 20, 40 mg/kg, i.p.) during treatment with d-galactose.  At the end of treatment, levels of malondialdehyde (MDA) as a lipid peroxidation marker and glutathione content (GSH) in the liver and brain were measured. Also, biochemical factors including liver enzymes (ALT and AST), male sex hormones including testosterone and dehydroepiandrosterone-sulfate (DHEA-SO4) and pro-inflammatory markers such as tumor necrosis factor -α (TNF-α) and interlukine-6 (IL-6) in serum, were evaluated. Results: Administration of d-galactose led to induction of lipid peroxidation in liver and brain tissues, as well as elevation of AST, ALT, and pro-inflammatory cytokines and reduction of male sex hormones levels in serum. Interestingly, treatment of animals with crocin (10, 20 and 40 mg/kg) diminished lipid peroxidation in the liver and brain tissues while elevated GSH content. Also, a decline in serum levels of TNF-α and IL-6 and an elevation of male sex hormones were observed following treatment with crocin. Conclusion: Administration of crocin reduced d-galactose-induced aging in mice through inhibition of oxidative stress, reduction of inflammation and elevation of sex hormones.

نویسندگان

Elaheh Mohammadi

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Soghra Mehri

Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Hasan Badie Bostan

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Hosseinzadeh

Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

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  • Alavizadeh SH, Hosseinzadeh H. 2014. Bioactivity assessment and toxicity of ...
  • Anderson FH, Zeng L,Rock NR, Yoshida EM. 2000. An assessment ...
  • Asadi MH, Zafari F, Sarveazad A, Abbasi M, Safa M, ...
  • Bahashwan SA, Hassan MH, Tamer M. Abdelghany TM,Gamil MA.  Ghobara ...
  • Ghanbari S, Yonessi M, Mohammadirad A, Gholami M, Baeeri M, ...
  • Hadizadeh F, Mohajeri SA, Seifi M.. 2010. Extraction and purification ...
  • Hadzi-Petrushev N, Stojkovski V, Mitrov D, Mladenov M. 2014. D-galactose ...
  • Haider S, Liaquat L, Shahzad S, Sadir S, Madiha S, ...
  • Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. ...
  • Hosseinzadeh H, Abootorabi A, Sadeghnia HR 2008. Protective effect of ...
  • Hosseinzadeh H, Sadeghi Shakib S, Khadem Sameni A, Taghiabadi E. ...
  • Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA. ...
  • Hsieh HM, WM Wu, Hu ML. 2009. Soy isoflavones attenuate ...
  • Jauslin ML, Vertuani S, Durini E, Buzzoni L, Ciliberti N, ...
  • Jin SL and Yin YG. 2012. In vivo antioxidant activity ...
  • Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, ...
  • Kumar A, Prakash A, Dogra S. 2011. Centella asiatica attenuates ...
  • Lan Z, Liu J, Chen L, Fu Q, Luo J, ...
  • Lari P, Abnous KH, Imenshahidi M, Rashedinia M, Razavi M, ...
  • Li K, Li Y, Ma Z, Zhao J. 2015. Crocin ...
  • Lu J, Zheng YL, Luo L, Wu DM, Sun DX, ...
  • Maggio M, Basaria S, Ceda GP, Ble A, Ling SM, ...
  • Mehri S, Abnous KH, Khooei A, Mousavi SH, Motamed Shariaty ...
  • Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, ...
  • Mohamadpour AH, Ayati Z, Parizadeh MR, Rajbai O, Hosseinzadeh H. ...
  • Mohammadirad A, Aghamohammadali-Sarraf F, Badiei S, Faraji Z, Hajiaghaee R, ...
  • Mollazadeh H, Emami SA,Hosseinzadeh  H. 2015. Razi’s Al-Hawi and saffron ...
  • Moron MS, Depierre JW, Mannervik B. 1979. Levels of glutathione, ...
  • Nam KN, Park YM, Jung HJ, Lee JY, Min BD, ...
  • Nazem H, Modaresi M, Messripour M,  Asadi M, Ebadi A. ...
  • Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. ...
  • Rikans LE and Hornbrook KR. 1997. Lipid peroxidation, antioxidant protection ...
  • Ruan Q, F Liu, , Gao Z, Kong D, Hu ...
  • Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. ...
  • Uchiyama M and Mihara M.1978. Determination of malonaldehyde precursor in ...
  • Umare V, Pradhan V, Nadkar M, Rajadhyaksha A, Patwardhan M, ...
  • Wang D, Liu M, Cao J, Cheng Y, Zhuo C, ...
  • Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, ...
  • Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, ...
  • Zhen YZ, Lin YJ, Li KJ, Zhang GL, Zhao YF, ...
  • Zheng YQ, Liu JX, Wang JN, Xu L. 2007. Effects ...
  • Zhong SZ, Ge QH, Qu R, Li Q, Ma SP. ...
  • نمایش کامل مراجع