Prevalence of fungal biofilms in patients with nasal polyposis: a systematic review

Introduction: There are many internal and external factors that are considered as the main causes of nasal infections and inflammation in chronic rhinosinusitis (CRS) leading to polyposis. It is suggested that bacterial and fungal elements have an important role in the development of these diseases. Method: Scopus and PubMed were searched thoroughly on 1 February 2015 with the following search terms: (fungal biofilms) AND (nasal polyposis) to find the articles in which the prevalence of fungal biofilms had been evaluated in patients with nasal polyposis. Only English language articles with no time limitation were included in this study.Result: Of 48 records found by initial search, only 10 articles met the inclusion criteria. Data showed that the presence of biofilms is associated with nasal polyposis in 110 of 303 patients and 13 of controls.Discussion: The results of studies confirm that the fungal biofilms play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis.Conclusions: According to the results of included studies, there is a close association between the presence of fungal biofilm and different types of nasal disorders including nasal polyposis.

کلیدواژه ها:

Biofilms ، Nasal mucosa ، Nasal Polyps