Comparison of Elevated Liver Enzymes in Type 2 Diabetic Patients in User and Non-User of Statin

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 273

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شناسه ملی سند علمی:

JR_INJPM-6-12_015

تاریخ نمایه سازی: 18 تیر 1398

چکیده مقاله:

Background: Type-2 diabetes is a risk factor for progressive non-alcoholic fatty liver disease and the majority of diabetic patients have blood lipid disorders, so they take statin drugs. Statins have the adverse effects such as liver dysfunction and increase in liver enzymes. The purpose of this study was to compare the liver enzymes in type 2 diabetic patients who are user and non-user of statin.Methods: In a case-control study, increased liver enzymes (ALT and AST > 40 U/L) were measured in blood samples of 200 type II diabetic patients (with and without statin consumption) who referred to Mashhad Diabetes Clinic in Mashhad city (Iran), during May to November 2017. Levels of liver enzymes and anthropometric indices were measured for both groups. Liver enzymes were assessed at the baseline of two groups. The SPSS 20th software was used for data analysis.Results: The mean of Body mass index in two groups of diabetic patients with and without statin consumption had a significant difference (p

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نویسندگان

Majid Rajabian

Faculty Member of Payame Noor University, Mashhad, Iran.

Elham Hussein Nejad

Master of Biochemistry, Payame Noor University, Mashhad, Iran.

Habibolah Taghizade Moghaddam

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.