Efficacy of the Application of the Human Amniotic Membrane (HAM) on the Management of Healing Process of Skin Wounds and Burns

Background: skin wounds are one of the major health problems in several countries. Many individuals are affected by skin wounds and burns in Iran, with a dressing cost more than several million dollars annually. The current study has done to evaluate the efficacy of the application of the human amniotic membrane (HAM) on the management of wound healing process.Methods: patients divided into two groups: group C (control) and T (treated with the HAM). The macroscopic evolution in the wound area and the histological characteristics of the skin samples were evaluated.Results: The skin wounds of patients were evaluated macroscopically after different periods of time (to 21 days) in terms of the formation of a scab and reduction in the wound area. The histological analysis revealed a significant reduction in the inflammatory infiltrate in group T at all experimental periods compared with that in the control group.Conclusion: The application of human amniotic membrane (HAM) fragments modulated the cascade of biological events from extensive tissue injuries, reduced wound regression and inflammatory response, and increased fibroblast proliferation and early stimulation of the production and organization of collagen fibers. Besides meeting the functional goals of the reconstructed skin, the results obtained are important given the reduction in the total time of the wound healing process and the final appearance observed.