Hematological and coagulation evaluation of neonates born of mothers with pre-eclampsia/eclampsia on the first day of life

Preeclampsia and eclampsia syndrome is associated with some adaptive changes in the fetal circulation that can cause a marked disturbance in the hematologic and hemostatic system of the mother and the neonate lead to a serious neonatal complication such as sepsis and bleeding manifestations.Materials and Methods: This observational descriptive study has been conducted in the nursery of Imam-Hossain Hospital from 2014 to 2017 on 104 term and late preterm neonates born to preeclamptic/eclamptic mothers. For every term and late preterm newborn (gestational age more than 34 weeks) Cell Blood Count (CBC) and Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) requested 6 hours after birth.Neonatal data including gestational age, gender, mode of delivery, birth weight and laboratory reports of laboratory data has been extracted from their medical records and analyzed.Results: The results in this study demonstrated that the abnormality in mean leukocyte count (P=0.03), hemoglobin (P=0.0001), platelet (P=0.0001) and the PT (P=0.003), PPT (P=0.001), and INR (P=0.003)are more significant in the late preterm than term neonate.The laboratory disorders in our study were neutropenia in 15 cases (14.4%), anemia in 18 (17.3%), leucopenia in 23 (22.1%), and thrombocytopenia in 28(26.9%).Thirty -two patients (30.7%) developed coagulation disorders with prolonged PT or /and PTT. onclusion:The present study has been done to find out the prevalence of the hematological and coagulation profile abnormality of the healthy newborn from mothers with preeclampsia/eclampsia. Although we could not follow them for the sequel of these disorders, future study is needed to evaluate the necessity and benefits of early hematological screening of these newborns

کلیدواژه ها:

Coagulation disorders ، Cell Blood Count (CBC) ، Newborn ، Pre-eclampsia ، Eclampsia