Pediatric Inflammatory Myofibroblastic Tumors of the Airway: Two Case Reports with Varying Clinical Presentation

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 238

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شناسه ملی سند علمی:

JR_IJOTO-30-3_008

تاریخ نمایه سازی: 12 تیر 1398

چکیده مقاله:

Introduction: An inflammatory myofibroblastic tumor (IMT) is a rare tumor of intermediate malignant potential. It may occur in a wide range of anatomical locations. One-third are found in the respiratory tract. We report two cases of IMT of the airway diagnosed at our institution.   Case Report: Case 1: A 6-year-old male child presented with a 1-month history of hoarseness of the voice. On evaluation, a polypoid nodule was noted in the right vocal cord which was excised through the endolaryngeal route. Histopathology was suggestive of anaplastic lymphoma kinase (ALK)-negative IMT. He presented with recurrence after 4 months, for which he underwent endolaryngeal reexcision and tracheostomy for airway protection. A third recurrence after 6 months was managed with laser excision, and the patient was started on oral celecoxib. After 1.5 years of follow up, endoscopic examination showed no recurrence, and celecoxib was continued. Case 2: A 7-year-old male child presented with cough and respiratory distress. Bronchoscopy and high resolution computed tomography showed a polypoidal lesion with calcification arising from the left anterolateral wall of the trachea with significant narrowing of the lumen. The patient underwent biopsy followed by endoscopic excision, and was diagnosed with IMT. Currently the patient is under follow up with no recurrence.   Conclusion: IMT indicates a proliferative myofibroblastic growth. Surgical resection should be recommended for all lesions if not prohibited by anatomic location or morbidity. Patients should be followed up closely for recurrence. In most cases, complete surgical excision will suffice; however multiple recurrences can be managed with chemotherapy. These two cases highlight the importance of a multidisciplinary approach in rare tumors in difficult anatomical locations.

نویسندگان

Nuthan Kumar

Department of Pediatric Hematology and Oncology, Kanchi Kamakoti Childs Trust Hospital And The Childs Trust Medical Research Foundation, Nungambakkam, Chennai – ۶۰۰۰۳۴,Tamil Nadu State, India.

Thirunavukkarasu Saravanamuthu

Department of Pediatric ENT, Kanchi Kamakoti Childs Trust Hospital And The Childs Trust Medical Research Foundation, Nungambakkam, Chennai – ۶۰۰۰۳۴,Tamil Nadu State, India.

Arathi Srinivasan

Department of Pediatric Hematology and Oncology, Kanchi Kamakoti Childs Trust Hospital And The Childs Trust Medical Research Foundation, Nungambakkam, Chennai – ۶۰۰۰۳۴,Tamil Nadu State, India.

Thulasiraman Ramalingam

Department of Pathology, Kanchi Kamakoti Childs Trust Hospital And The Childs Trust Medical Research Foundation, Nungambakkam, Chennai – ۶۰۰۰۳۴,Tamil Nadu State, India.

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