Synthesis and characterization of new Schiff Base N-donor ligands with metal complexes and investigation of biological effect of them

Schiff bases, named after Hugo Schiff [1], are formed when any primary amine reacts with an aldehyde or a ketone under specific conditions. Structurally, a Schiff base (also known as imine or azomethine) (Fig. 1) is a nitrogen analogue of an aldehyde ketone in which the carbonyl group (C = O) has been replaced by an imine or azomethine group.Schiff bases are some of the most widely used organic compounds. They are used as pigments and dyes, catalysis, intermediates in organic synthesis, and as polymer stabilisers [2].Schiff bases have also been shown to exhibit a broad range of biological activities, including antifungal, antibacterial. antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties [2,3]. Imine or azomethine groups are present in varios natural, naturalderived, and non-natural compounds (see Fig. 2 for some examples). The imine group present in such compounds has been shown to be critical to their biological activities.In this research work,No, Schiff base ligand prepared of 2-amino benzoic acid with 3-nitro benz aldehyde. Zn(II), Cu(II) and Ni(II) Schiff base complexes of this ligand were synthesized. the Schiff base ligand and related complexes were characterized by IR, UV-Vis, NMR, Mass spectrometry