Synthesis, characterization, DNA binding studies of Pd (II) antitumor complexes

Two new palladium complexes [Pd (8-QO)(AA)] (where 8-QO= 8-hydroxyquinoline and AA= amino acids with hydrocarbon (hydrophobic) side chains such as glycine and valine) have been synthesized by reaction between sodium salt of respective amino acid and Na2 [PdCl4] and subsequent addition of 8-hydroxy quinoline. The molar ratio of the three reactant was 1:1:1. This complexes have been characterized by FT-IR, UV-Vis and 1H-NMR spectroscopic techniques and conductivity measurements. The novel antitumor Pd (II) complexes were evaluated for its binding to CT-DNA in physiological buffer (pH=7) by using absorption spectroscopy, fluorescence titration spectra studies. The result obtained from these analyses indicated that the complexes can bind to DNA cooperatively through astatic quenching procedure [1-3].