Invasion and Migration in Breast Cancer, bench to bedside researches

Background: Breast cancer is the most frequent malignancy among women, impacting 2.1 million women each year and causes the greatest number of cancer-related deaths in them. Limited resource settings with weak health systems make the majority of women are diagnosed in late stages. So many of the cells are invaded locally or migrated far away.Objectives: The present review focuses on various types of in-vitro and in-vivo research methods on breast cancer cell movement and probable therapeutic potentials. Methodology: We searched related keywords in common medical databases. English articles extracted and evaluated.Results: Researchers answer many questions in this regard about how cells adhere, move and migrate. They have suggested Three-step model of invasion . There are so many methods for in-vitro invasion and migration assay. Different cells cane use for inhibition of invasion and migration in breast cancer cells. Conclusion:The process of invasion is dependent on the successful coordinated timing and activity of multiple tumor cell and host cell molecules. Stem cell therapy is one of the most promising and newest approaches in clinical and basic setting in breast cancer management.

کلیدواژه ها:

: Invasion ، Migration ، Breast cancer ، Cell-based therapy ، Stem cell ، Review article