A THREE DIMENSIONAL HTLV-1 MODEL WITH INTRACELLULAR AND IMMUNE ACTIVATION DELAYS

In this paper, a three dimensional mathematical model for HTLV-1infection with intracellular delay and immune activation delay is investigated.By applying the frequency domain approach, we show that time delays candestabilize the HAM/TSP equilibrium, leading to Hopf bifurcations and sta-ble or unstable periodic oscillations. At the end, numerical simulations areillustrated.

کلیدواژه ها:

CTL response ، Graphical Hopf bifurcation theorem ، Fre- quency domain ، Delay di erential equation ، HTLV-1 infection