The application and formation of inclusion complex of γ-cyclodextrin with turmeric

Gama-cyclodextrin (γ-CD) is one of cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules or fragments of large compounds. γ-CD is also used for increasing stability and bioavailability of drugs, and other additional applications [1]. This research is to synthesize and characterization the inclusion complex of gama-cyclodextrin (γ-CD) with turmeric which has antioxidanting activity property. The interaction inclusion complex was characterized by fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) spectroscopies at 25°C. UV-vis spectra were analysised of turmeric/γ-CD complex at maximum wavelength 418 nm of turmeric in 0.06 mM concentration with methanol. The formation constant was calculated by using a modified Benesi-Hildebrand equation to number of 5.9×105 M-1. The stoichiometry of inclusion complex was found by using of Job s plot to be 1:1 for γ-CD with turmeric.Turmeric, is a yellow pigment extracted from the ground rhizome of curcuma commonly used as a spice and food colorant [2]. The aim of research has the antioxidant activity of turmeric and its inclusion complex were determined by the scavenging of stable radical 2,2՜-diphenyl-1-picrylhydrazyl (DPPH˙) [3]. Kinetic studies were done to remove DPPH˙ in presence turmeric and turmeric/γ-CD complex at amount more of 100%. The spectra shown interaction between the OH group of γ-CD and the phenolic hydroxyl group of turmeric. The results were indicated that the turmeric/γ-CD inclusion complex most reactive than its free form into antioxidant activity. Therefore γ-CD can used to enhance turmeric solubility in aqueous solutions for pharmaceutical applications