Synthesis pyrimidin- 5-yl-pyrroles derivatives

Barbiturates are related to pyrimidines and their activities vary by changing the alkyl groups present in the C-5 position [1]. Reactions modifying this position are thereforeparticularly useful. Scaffolds containing the pyrrole core are found in numerous drugs, natural products and biological systems. Several methods have been developed for the synthesis of pyrrole analogues [2] as a clear indication of the important role pyrrolyl heterocycles play in synthetic and medicinal chemistry [3]. Herein a simple and an efficient three-component domino method for the synthesis of poly-functionalized pyrimidin- 5-yl-pyrroles 5 (Scheme 1) from a three-component domino reaction of enaminone derivatives 4, barbituricacid 1 and arylglyoxalhydrates 2 under mild reaction conditions has been developed.