Synthesis of new selective ligand from N-Aryltrifluoroacetimidoyl chlorides and aniline derivatives

Trifluoromethylated compounds are of particular interest as the strong electronwithdrawing effect of the CF3 group contributes to a number of biologically important molecular properties. For example, it results in a significant increase in the lipophilicity of the molecule, which is a very important feature in drug delivery. NAryltrifluoroacetimidoyl chlorides can be prepared by several procedures [1, 2]. Herein we wish to report we now report synthesis of new selective ligand 2,2,2-trifluoro-N,N -diphenyl-N-((2,2,2-trifluoro-1-(phenylimino)ethyl)acetimidamide 3 based on the reaction of trifluoromethylimidoyl chlorides 1 with the aniline derivatives 2 inthe presence of base (scheme 1). The structures of this products were proved by 1HNMR, 13C-NMR, 19F-NMR and IR spectral data and elemental analysis.