Synthesis of 2,2,2-trifluoro-N-phenyl-1-tosylethan-1-imine derivatives

The progress in the field of fluorination organic compounds has been summarized in numerous review articles. It was considered that the fluorine atoms or fluorinated compounds play a pivotal role in bioactive compounds, because they provide an avenue for further structural elaboration. In recent years, various fluoroalkylation reagents and reactions such as trifluoromethylation, difluoromethylation, and monofluorome-thylation have been extensively investigated, in order to synthesis new organofluorine compounds [1]. Sodium aryl sulfinate are important structures in bioactive compounds [2]. Synthesis of such molecules, however, usually requires cumbersome synthetic routes. Herein a simple and an efficient for the synthesis of 2,2,2-trifluoro-N-phenyl-1-tosylethan-1-imine derivatives 3 (Scheme 1) from of trifluoroacetimidoyl chloride derivatives 2, Sodium Aryl sulfinate 1 under mild reaction conditions has been developed.