Fe3O4@Cu-β-CD nanoparticles-catalyzed synthesis of pyrazole derivatives

Regarding to the incrementing environmental contamination and also due toadvantages of water as a solvent including environmentally safe, vast accessibility, non-flammability and cost-effective, use of such confident solvent have recently attracted the heed of chemists to its application in organic reaction [1,2]. The solubility of reactants in water boosts by using of β-CD through host–guest complexation. Cu nanoparticles have been recently shown to be efficient catalyst for some important reactions [3]. This paper is a report on the synthesis of the Fe3O4@Cu-β-CD core-shell. The cost effective and recyclable Fe3O4@Cu-β-CD nanocomposites provide an exciting new material for environmental protection applications. TEM, XRD, EDS and FT-IR were used to characterize the Fe3O4@Cu- β-CD nanocomposites. This new catalyst was used for four-component synthesis of pyrazole derivatives in aqueous solution under mild conditions (Scheme).