The magnetic Co1-xZnxFe2O4 nanostructure interaction with DNA molecule study by multiple spectroscopies

Over the past few years, magnetic nanoparticles (NPs) have become more and more significant for applications in biomedicine and biotechnology. Cobalt ferrites NPs areappropriate for the isolation and purification of genomic DNA and particularly in hyperthermia treatment. In this research, we have studied the interaction between synthesized Co1-xZnxFe2O4nanostructure and DNA molecule using UV-Visible spectroscopy, Fluorescence spectroscopy and Fourier-transform infrared spectroscopy (FTIR) at 37 ˚C. The UV-Visible spectroscopy results suggested that after adding different concentrations of the Co1-xZnxFe2O4 nanostructure to the DNA solution, the DNA structure changed. Furthermore, the fluorescence studies revealed the strong interaction between DNA and Co1-xZnxFe2O4 nanostructure occurred. The FTIR studies displayed the variations in bending and stretching bonds of functional groups of DNAdue to the interaction with Co1-xZnxFe2O4. The results obtaining from this present study probably provide useful information to design more efficiency magnetic anti-cancer drugs in the future.

کلیدواژه ها:

DNA ، Cobalt–Zinc Ferrite Nanostructure ، Spectroscopy ، Magnetic nanostructure