Evaluation of the effects of ceftriaxone chronic treatment on anxiety disorders in the pilocarpine model of temporal lobe epilepsy

Epilepsy is one of the most common neurological disorders in humans that affects all ages. The antibiotic ceftriaxone with the ability to cross the blood-brain barrier and the effect on the mediating level of glutamate in the brain is a good alternative to curative treatment. Therefore, this study examines the chronic administration of this drug to the Temporal Lobe epilepsy model. 35 male rats were randomly selected from 200 to 250 grams. Animals were divided into 4 groups: 1.The control group (N=7, animals received vehicle) 2. Pil group (N=7, animals received pilocarpine and Status Epilepticus was induced) 3. Pil+Cef group (N=7, animals received pilocarpine and daily administration of Ceftriaxone 200mg/kg for 5 days) 4. Cef group (N=7, animals only received 5 administration of Ceftriaxone). Results show that Pilocarpine significantly increases anxiety measured as the reduction in time spent in the open arm of the Elevated plus maze, as well as time and distance traveled in the center of the open-field test. Chronic ceftriaxone treatment can significantly increase open arm entrance and time spent in open arm of the EPM as well as time and distance moved in the center of the open-field. These results suggest that Ceftriaxone can reduce anxiety induced by Temporal lobe epilepsy, probably through upregulating glutamate transporter GLT-1.

کلیدواژه ها:

Elevated Plus maze ، Open field ، Temporal lobe epilepsy ، Ceftriaxone