Evaluation of the effect of microgravity on the development of liver remak structure in rat embryos and the therapeutic effect of folic acid

Microgravity has many effects on the physiological systems and studying these changes is useful to help astronauts, improve human life and to answer biology questions. The aim of the present study was to investigate the impact of microgravity on the development of liver remak in rat embryos and the therapeutic effect of folic acid. Fertilization animals were randomly divided into five groups of six members: control group, the first experimental group who were exposed to microgravity (days 10-15 of pregnancy-5 days of weightlessness), the second experimental group who received an edible daily dose of folic acid (days 10-15 of pregnancy), the third experimental group who were exposed to microgravity (days 1-20 of pregnancy-20 days of weightlessness), the fourth experimental group who received folic acid and exposed to microgravity (days 10-15 of pregnancy-5 days of weightlessness). On the 20th day of pregnancy, the embryo was removed stained using H&E and studied under the microscope. The results indicated that exposure to microgravity can cause a significant decrease in the natural structure of liver remak and damage to remak sheets; however folic acid consumption can improve it.

کلیدواژه ها:

Microgravity ، Remak structure ، Liver tissue ، Embryo ، Rat