Evaluation of serum Irisin level in high fat emulsion diet induced nonalcoholic fatty liver disease in Sprague-Dawley rats

Irisin is a myokine that mainly produces by skeletal muscles. Irisin play an important role in glucose metabolism and energy balance and improves glucose metaboliThis study aimed to evaluate the serum irisin level and UCP1 gene expression in adipose tissue in rat model of Nonalcoholic fatty liver disease (NAFLD).Eighteen male Sprague-Dawley rats were divided into normal control group and high fat emulsion model group. All rats were provided with standard rodent chow and water. The model rats were orally treated with the high fat emulsion diet once per day via gavage for six weeks. High fat emulsion diet was prepared with corn oil and cholesterol. After six weeks, serum Irisin level, glucose, insulin, insulin resistance, FFA, TNFa, serum lipid profile and MDA in liver had significantly increased in high fat emulsion group but UCP1 gene expression had not significantly increased in adipose tissue of high fat emulsion group.In this study administration of high fat emulsion diet increased insulin resistance and serum irisin level in high fat emulsion model group. The higher Irisin level could be a protective response to early glucose impairments or a symptom of irisin resistance

کلیدواژه ها:

onalcoholic fatty liver disease ، Thermogenesis ، Myokine ، Irisin ، Insulin resistance