60 Years old woman with anemia and lyticbone lesion with diagnosis of GAUCHER disease

Background:GD is one of the most common glycolipid storage disorders, caused by inherited deficiency of the lysosomal enzyme β-glucocerebrosidase, leading to accumulation of the substrate glucocerebroside in the cells of the macrophage- monocytesystem. The clinical manifestations of GD result from the accumulation of the lipid-laden macrophages in the spleen, liver, bone marrow, bone, and other tissues/organs.Case reports:We reported 60 Yrs old patient that presented with weakness, pallor ,and bone pain from years ago. She had undergonedifferent treatment with another diagnosis. After bone marrow aspiration and biopsy final diagnosis of GAUCHER disease was reveald.Conclusion:We report case of G.D. to emphasize that G.D should be considered in the differential diagnosis of patients with bone pain and anemia .our patient did not have hepatosplenomegalyand she had 60 years old. On the other hand she had undergonradiotherapy and physiotherapy due to other diagnosis. The diagnosis of GD need to clinical suspicious and reminder that the disease can be seen at any age and without hepatosplenomegaly