Enrichment analysis of hsa-miR-320b most related pathways in cancer

Introduction: Cancer is complex disease in which the expression of the gene is unbalanced.MicroRNAs are group of non-coding RNAs that have length of about 18 to 25 nucleotides and,after transcription, affect the expression of the gene. In fact, microRNAs act as biomarkers toregulate the expression of genes at the mRNA level and act as an oncomiR or tumor suppressor.transcription, affect the expression of the gene. They do this by completing the complementarysequence, which is often targeted at the mRNA region of the 3’UTR.Importance of research: Recent studies have shown important roles in many biological functionsfor these RNAs, including the role they play in cancer-related processes. For this purpose,bioinformatics studies are required to explore the comprehensive molecular function of themicroRNAs in cancers.Materials and Methods: By considering the role of hsa-miR-320b in cancer, for obtainingpredicted targets of hsa-miR-320b, MIMAT ID of active arm was picked from miRBase databaseand inserted in miRWalk2.0 database. Finally, for obtaining the most related pathways of hsa-miR320b, the entrez IDs of predicted targets were inserted into DAVID database.Results: Our data manifested KEGG signaling pathways GLIOMA and PANCREATIC CANCER and PROSTATE CANCER and MELANOMA and CHRONIC MYELOID LEUKEMIA as themost statistical relevant pathway with hsa-miR-320b targetome.Conclusion: Information from all of above signaling pathways indicates that microRNA Part of theMAPK signaling pathway route targets the ERK gene And with this targeting the ERK geneprevents cell growth and proliferation. According to these studies, it is predicted that hsa-miR-320bacts as tumor suppressor microRNA that prevents the activation of number of genes that areinvolved in the process of cell growth and proliferation and may be in prognosis of cancer byaltering some of the signaling vital ones