Castleman’s disease with TAFRO syndrome: The first case from Iran

Introduction: TAFRO syndrome is new presentation of idiopathic multicentric Castlemandisease which is termed as thrombocytopenia, anasarca, fever, reticulinmyelofibrosis andorganomegaly. The exact pathophysiology of TAFRO syndrome is unclear and management ismostly based on case reports and expert opinion.Materials Methods: Histologic findings of bone marrow, skin, kidney and lymph node biopsyand other laboratory findings of the 37 year old male has been provided.Results: The patient was referred with fever, sweating, anorexia, abdominal distension andgeneralized edema which has been hospitalized multiple times. The patient also developed skinlesions dispersed in red nodules, which was reported as granuloid hemangioma Renal biopsyreported mesangioprolifrative glomerulonephritis and bone marrow specimen showed hypercellularmarrow with reticulin fibrosis. The lymph node biopsy was reported as Castleman disease.Conclusions: Different manifestations of TAFRO syndrome may overlap with other syndromes andcan be managed by corticosteroids, tocilizumab, retuximab, and bortezomib.