Different breast cancer subtypes in women more than 65 years old

Introduction: Breast cancer is the most common malignancy of females. Breast cancer is a heterogenic disease; it consists of several subtypes based on expression of different genes. risk factors associated with each subtype is not completely understood yet. Moreover, recognizing the cancer subtype may alter the treatment plan. The aim of this study was to evaluate different breast cancer subtypes in women more than 65 years old. Methods: This was a cross-sectional study done on breast cancer patients aged 65 years and older presenting to clinics of Emam Reza and Omid Hospitals, Mashhad, Iran between 2005 and 2015. Statistical analysis was carried out using SPSS ver. 16. P<0.05 was considered statistically significant. Results: A total of 225 breast cancer patients age 65 and older were included in our study. When we categorized our patients by breast cancer subtypes 69.8% had the Luminal A, B subtype, 23.1% had Triple-Negative subtype and the remaining 7.1% had HER-2 enriched subtype. Conclusion: Different breast cancer subtypes in patients aged 65 years old and higher were Luminal A, B, HER-2 enriched and Triple-negative, respectively. We also showed that patients with Luminal A, B subtypes had significantly higher BMI and BSA compared to other subtypes.

کلیدواژه ها:

Breast cancer ، Diagnosis ، Age ، Metastasis